| 超临界CO2在制备PCL/水杨酸甲酯控释体系中的应用研究 |
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| 引用本文： | 胡银春,许群,李建波,后振中,范海娟. 超临界CO2在制备PCL/水杨酸甲酯控释体系中的应用研究[J]. 世界科技研究与发展, 2007, 29(3): 22-26 |
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| 作者姓名： | 胡银春 许群 李建波 后振中 范海娟 |
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| 作者单位： | 郑州大学材料科学与工程学院,郑州,450052;郑州大学材料科学与工程学院,郑州,450052;郑州大学材料科学与工程学院,郑州,450052;郑州大学材料科学与工程学院,郑州,450052;郑州大学材料科学与工程学院,郑州,450052 |
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| 摘 要： | 本文利用超临界二氧化碳（SCCO2）对生物可降解材料--聚己内酯（PCL）进行溶胀和塑化,进而将其作为携带剂,将水杨酸甲酯嵌入到PCL中,制备含有水杨酸甲酯的PCL多孔材料,即PCL/水杨酸甲酯控释体系,并研究超临界流体条件下水杨酸甲酯的插嵌规律.研究结果表明,PCL对水杨酸甲酯有很好的吸附能力,通过测定所制备的多孔材料PCL/水杨酸甲酯体系的缓释行为,表明其多孔结构对药物分子具有一定的缓释功能,药物分子释放时间最长可达18 h以上.
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| 关 键 词： | 超临界二氧化碳 聚己内酯 水杨酸甲酯 缓释材料 |
The Assistance of Supercritical Carbon Dioxide in the Preparation of PCL/Methyl Salicylate Controlled-Release System |
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| HU Yinchun,XU Qun,LI Jianbo,HOU Zhenzhong,FAN Haijuan. The Assistance of Supercritical Carbon Dioxide in the Preparation of PCL/Methyl Salicylate Controlled-Release System[J]. World Sci-tech R & D, 2007, 29(3): 22-26 |
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| Authors: | HU Yinchun XU Qun LI Jianbo HOU Zhenzhong FAN Haijuan |
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| Affiliation: | College of Materials Engineering, Zhengzhou University, Zhengzhou 450052 |
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| Abstract: | In this study,poly(e-caprolactone)(PCL),which was chosen as the polymer matrix,was swelled and plasticized in supercritical carbon dioxide(SC CO2).Then drug precursor methyl salicylate(MS) was impregnated and encapsulated into PCL using SC-CO2 as a carrier and swelling agent.The effects of temperature,pressure and concentration of drug precursor on drug loading amount were studied.The release behaviors of the controlled-release systems with different drug loading amounts were also investigated. |
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| Keywords: | supercritical carbon dioxide polycaprolactone methyl sallcylate controlled-release material |
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