| P2Y12反应性和血小板抑制率在预测ACS患者PCI术后长期预后中的作用 |
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| 引用本文： | 李小林,罗裕,柳永华,刘中文,范成辉,欧军萍. P2Y12反应性和血小板抑制率在预测ACS患者PCI术后长期预后中的作用[J]. 井冈山大学学报(自然科学版), 2021, 42(3): 96-101 |
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| 作者姓名： | 李小林 罗裕 柳永华 刘中文 范成辉 欧军萍 |
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| 作者单位： | 井冈山大学医学部,江西,吉安 343009;上海市东方医院吉安医院心内科,江西,吉安 343000;同济大学附属上海市东方医院心内科,上海 200120;保山市人民医院心脏科,云南,保山 678000;上海市东方医院吉安医院心内科,江西,吉安 343000 |
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| 基金项目： | 江西省教育厅科学技术项目（GJJ180579）；井冈山大学博士科研启动项目（JZB1820） |
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| 摘 要： | 目的 探讨P2Y12反应性和血小板抑制率在ACS患者PCI术后发生心肌缺血事件的价值.方法 采用VerifyNow P2Y12系统检测P2Y12反应性和血小板抑制率,计算ACS患者术后30天COP-INH值.综合分析COP-INH评分与主要终点事件的相关性.结果 在226例受试者中,在排除糖尿病(46.15％vs.21...
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| 关 键 词： | 血小板反应性 氯吡格雷 急性冠状动脉综合征 经皮冠状动脉介入治疗 预后 |
| 收稿时间： | 2020-10-16 |
| 修稿时间： | 2020-12-26 |
VALUE OF P2Y12 REACTION AND PLATELET INHIBITION IN PREDICTING LONG-TERM CLINICAL OUTCOMES IN PATIENTS WITH ACUTE CORONARY SYNDROME (ACS) UNDERGOING PERCUTANEOUS CORONARY INTERVENTION (PCI) |
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| LI Xiao-lin,LUO Yu,LIU Yong-hu,LIU Zhong-wen,FAN Cheng-hui,OU Jun-ping. VALUE OF P2Y12 REACTION AND PLATELET INHIBITION IN PREDICTING LONG-TERM CLINICAL OUTCOMES IN PATIENTS WITH ACUTE CORONARY SYNDROME (ACS) UNDERGOING PERCUTANEOUS CORONARY INTERVENTION (PCI)[J]. Journal of Jinggangshan University(Natural Sciences Edition), 2021, 42(3): 96-101 |
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| Authors: | LI Xiao-lin LUO Yu LIU Yong-hu LIU Zhong-wen FAN Cheng-hui OU Jun-ping |
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| Affiliation: | School of Medicine, Jinggangshan University, Ji''an, Jiangxi 343009, China;Department of Cardiovascular, Ji''an Hospital, Shanghai East Hospital, Ji''an, Jiangxi 343000, China;Department of Cardiovascular, Affiliated Shanghai East Hospital, Tongji University, Shanghai 200120, China;Department of Cardiovascular, Baoshan People''s Hospital, Baoshan, Yunnan 678000, China |
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| Abstract: | Objective: To investigate the value of P2Y12 reaction and platelet inhibition in predicting the long-term ischaemic events in patients with ACS undergoing PCI. Methods: P2Y12 reaction and platelet inhibition rates were assessed by VerifyNow P2Y12 assay, the COP-INH was calculated according to the data obtained at 30 days after PCI. The relationship between the COP-INH score and primary endpoint was analyzed. Results: 226 patients were enrolled. There were no significant differences in clinical characteristics among the patients with COP-INH=2, 1 or 0, except for the patients with diabetes mellitus (46.15% vs. 21.93%, p=0.015) and previous coronary artery bypass grafting (23.08% vs. 7.49%, p=0.008). The incidence of major adverse cardiovascular events (MACE) in patients with COP-INH=2 was significantly higher than that in patients with COP-INH=1 or 0 (23.08% vs 5.88%, p=0.007). Multivariate analysis showed that the COP-INH=2 was an independent predictor of MACE in patients with ACS undergoing PCI (p=0.025), whereas there were no statistical significance in the differences of the patients with the COP-INH=1 or 0. Conclusion: The COP-INH is considered to be a useful predictor of long-term schaemic events of patients with ACS undergoing PCI. |
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| Keywords: | platelet reactivity clopidogrel acute coronary syndrome percutaneous coronary intervention prognosis |
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