| 反相高效液相色谱法测定己酮可可碱氯化钠注射液中的有关物质 |
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| 引用本文： | 刘放,周芝芳,孙洁胤. 反相高效液相色谱法测定己酮可可碱氯化钠注射液中的有关物质[J]. 浙江科技学院学报, 2003, 15(Z1): 54-55 |
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| 作者姓名： | 刘放 周芝芳 孙洁胤 |
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| 作者单位： | 浙江省医学科学院,药物研究所,浙江,杭州,310013 |
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| 摘 要： | 用RP-HPLC建立了己酮可可碱氯化钠注射液中有关物质的检测和控制方法.以Spherisorb C18柱和甲醇-0.1%冰醋酸(5050,1 mL/min),得到己酮可可碱及其有关物质基线分离,用UV检测器(波长264 nm)的最低检测量为4 ng,控制总杂质量不得过1.0%.该法简便、快速、准确,适用于己酮可可碱及其制剂的质量控制.
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| 关 键 词： | 己酮可可碱 己酮可可碱氯化钠注射液 有关物质 反相高效液相色谱法 |
| 文章编号： | 1671-8798(2003)S0-0054-02 |
| 修稿时间： | 2003-09-10 |
Determination of related substances in pentoxifylline and Sodium chloride injection by RP- HPLC |
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| LIU Fang,ZHOU Zhi-fang,SUN Jie-yin. Determination of related substances in pentoxifylline and Sodium chloride injection by RP- HPLC[J]. Journal of Zhejiang University of Science and Technology, 2003, 15(Z1): 54-55 |
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| Authors: | LIU Fang ZHOU Zhi-fang SUN Jie-yin |
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| Abstract: | To establish a method for the control of related substances in pentoxifylline and sodium chloride injection, a RP-HPLC method was developed. Chromatographic condition included a Spherisorb C18 colunm with the mobile phase of methanol and 0.1% glacial acetic acid (50:50). The UV detection wavelength was set up at 264 nm. The peak of pentoxifylline and its related substances were separated completely. The LOD was 4 ng. The method is simple, rapid and accurate. It can be used to control pentoxifylline and its preparations. |
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| Keywords: | pentoxifylline pentoxifylline and sodium chloride injection related substances RP-HPLC |
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