| 消渴通络颗粒改善糖尿病大鼠周围神经病变的作用 |
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| 引用本文： | 冯娟,吕艳青,刘福丹,严群超,叶春玲.消渴通络颗粒改善糖尿病大鼠周围神经病变的作用[J].暨南大学学报,2009,30(4). |
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| 作者姓名： | 冯娟 吕艳青 刘福丹 严群超 叶春玲 |
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| 作者单位： | 1. 暨南大学药学院药理学教研室,广东,广州,510632
2. 暨南大学医学院临床医学系,广东,广州,510632 |
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| 基金项目： | 广州市科技局科技攻关项目 |
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| 摘 要： | 目的:观察消渴通络颗粒对链脲佐菌素(STZ)诱发的糖尿病大鼠周围神经病变的影响.方法:采用腹腔注射链脲佐菌素制备糖尿病大鼠模型.成模大鼠随机分为模型组、阳性对照组、消渴通络颗粒高、中、低剂量组,分别用蒸馏水、质量分数为2.8 g/ks消渴丸、消渴通络颗粒质量分数分别为4.48、2.24、1.12 g/kg剂量每天1次灌胃,连续给药8周.8周后检测血清中超氧化物歧化酶(SOD)活性、丙二醛(MDA)以及血浆中一氧化氮(NO)浓度,用生物机能实验系统BL410软件测定大鼠坐骨神经传导速度的变化.结果:消渴通络颗粒能明显提高糖尿病大鼠血清中超氧化物歧化酶(SOD)活性和血浆中一氧化氮(NO)浓度、降低丙二醛(MDA)浓度(P<0.05或P<0.01),并能明显提高坐骨神经的传导速度(P<0.05).结论:消渴通络颗粒改善糖尿病大鼠周围神经病变导致的传导速度减慢,可能与抗氧化、升高一氧化氮(NO)等作用有关.
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| 关 键 词： | 消渴通络颗粒 糖尿病周围神经病变 抗氧化 糖尿病大鼠 运动神经传导速度 |
The amelioration effects of XiaoKeTongLuo granula on peripheral neuropathy in diabetic rats |
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| FENG Juan,LU Yan-qing,LIU Fu-dan,YAN Qun-chao,YE Chun-ling.The amelioration effects of XiaoKeTongLuo granula on peripheral neuropathy in diabetic rats[J].Journal of Jinan University(Natural Science & Medicine Edition),2009,30(4). |
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| Authors: | FENG Juan LU Yan-qing LIU Fu-dan YAN Qun-chao YE Chun-ling |
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| Institution: | 1.Department of Parmacology;Pharmacy College;2.Clinical Medicine;Medicine College;Jinan University;Guangzhou 510632;China |
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| Abstract: | Aim:To observe the effects of the XiaoKeTongLuo granula(XKTL)on the peripheral nervous disease in the diabetes rats induced by STZ. Methods: Six weeks old SD rats were injected streptozocin(STZ) intraperitoneally to prepare diabetic model.Then the diabetic rats were randomly divided into the model group,the positive control group,and the high,medium and low dosage groups of XKTL.The animals were given distilled water,Xiaokewan dosage 2.8 g/kg,XKTL different dosage 4.48,2.24,1.12 g/kg by intragastric adminis... |
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| Keywords: | XiaoKeTongLuo granula diabetic peripheral neuropathy antioxidation diabetic rats motor nerve conduction velocity |
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