Effect of cortisone or triiodothyronine administration to pregnant rats on lysosomal hydrolases in fetal forebrain and cerebellum |
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| Authors: | H. C. Lau Carolyn Horowitz Jocelyn Jumawan O. Koldovsky |
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| Affiliation: | (1) Division of Biochemical Development and Molecular Diseases, Children's Hospital of Philadelphia, 19104 Philadelphia, Pa., USA;(2) the Department of Pediatrics, Medical School of the University of Pennsylvania, 19104 Philadelphia, Pa., USA |
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| Abstract: | Summary Triiodothyronine injected daily to pregnant rats for the last week of gestation (50  g/100 g b.wt) increased the specific activities of 5 acid glycosidases in the fetal forebrain and cerebellum. Cortisone (50 mg/100 g b.wt) administered in the same period had no effect on cerebellum acid hydrolases, but decreased their activity in the forebrain.Supported by grant No. HD 08536 from the National Institutes of Health, Bethesda, Maryland. |
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