Hormone de croissance et sport |
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| Institution: | 1. Bremerhaven, Germany;2. Department of Epidemiology and Statistics, Boston University School of Medicine, Boston, Massachusetts;3. Department of Urology, Boston University School of Medicine, Boston, Massachusetts;1. Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan;2. Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan;3. Dementia and Parkinson’s Disease Integrated Center, Taichung Veterans General Hospital, Taichung, Taiwan;4. Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan;1. Department of Pharmaceutical Biology, Wroclaw Medical University, Borowska 211, 50-556, Wroclaw, Poland;2. Department of Physical Chemistry, Wroclaw Medical University, Borowska 211A, 50-556, Wroclaw, Poland;3. Department of Biology and Pharmaceutical Botany, Medical University of ?odz, Muszynskiego 1, 90-151, ?odz, Poland;4. Department of Fruit and Vegetable Technology, Wroc?aw University of Environmental and Life Sciences, J. Chelmonskiego 37/41, 51-630, Wroclaw, Poland;5. Student Scientific Club no K76, Department of Pharmaceutical Biology, Wroclaw Medical University, Wroclaw, Poland;6. Laboratory for Experimental Cultivation of Medicinal Herbs, Botanical Garden of Medicinal Plants, Wroclaw Medical University, Al. Jana Kochanowskiego 10/12/14, Poland;1. Forensic Toxicology and Chemistry Unit University Centre of Legal Medicine Lausanne – Geneva, CH-1011 Lausanne, Switzerland;2. Swiss Laboratory for Doping Analyses University Centre of Legal Medicine Lausanne – Geneva, CH-1066 Epalinges, Switzerland;1. Department of Physiological Sciences, Federal University of Espirito Santo, Vitória, Espirito Santo, Brazil;2. Department of Anatomy & Cell Biology, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA;3. Program in Medical Neurosciences, Paul and Carole Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA;4. Department of Pharmaceutical Sciences, University of Vila Velha, Vila Velha, ES, Brazil;1. Laboratory of Pharmacological and Toxicological Evaluations Applied to Bioactive Molecules, Federal University of Pampa, CEP 97650-000, Itaqui, RS, Brazil;2. Laboratory of Synthesis, Reactivity, Pharmacological and Toxicological Evaluation of Organochalcogen Compounds, Department of Biochemistry and Molecular Biology, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil |
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| Abstract: | Human growth hormone (hGH) is a peptide hormone composed of 191 amino acids. It is suspected to be abused in sport essentially because of its anabolic properties.Although its actual efficiency in the improvement of sport performances is not proved, the sports autorities put the growth hormone on the list of forbidden compounds. The detection of hGH is still making problem to the analysis. Two approaches are proposed. First, the detection by the secondary parameters, called indirect method, is based on the biological parameters bound to hGH and which half-life is longer as IGF-1, IGFBP-3 and the glycoprotein ALS. Furthermore, the biological parameters characteristic of bone turnover are also candidates to establish a diagnostic constellation. Secondly, the direct method is based on the ratio between the different pituitary isoforms of the hormone and on the change induced by an injection of recombinant hGH, which is composed only by the 22kDa isoform. |
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