Le virus epstein-barr : structure et cycle biologique |
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| Institution: | 1. Hôpital Rothschild Service de virologie 33, bd de Picpus 75571 Paris cedex 12, France;1. Pharmacie à usage intérieur, centre hospitalier régionale universitaire de Nancy, allée du Morvan, 54511 Vandoeuvre-lès-Nancy, France;2. Pharmacie à usage intérieur, hôpital Saint-Charles, 54201 Toul, France;3. Université de Lorraine, EA 4360 APEMAC, 54000 Nancy, France;1. Laboratory of Molecular and Cellular Screening Processes, Centre of Biotechnology of Sfax, University of Sfax, Route Sidi Mansour, Po Box 1177, 3018 Sfax, Tunisia;2. Department of Histology, Faculty of Medicine of Sfax, Majida Boulila Avenue, 3028 Sfax, Tunisia;3. Cardiology Service, Hedi Chaker University Hospital Sfax, El Ain Road, 3029 Sfax, Tunisia;1. Institute of Medical Epidemiology, Biostatistics and Informatics, Medical Faculty, Martin-Luther-University Halle-Wittenberg, Germany;2. Section of Cancer Information, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France;3. Department of Medicine, University of Zimbabwe School of Medicine, Harare, Zimbabwe;4. Department of Pathology, Maputo Central Hospital, Maputo, Mozambique;5. CTSU, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7FL, United Kingdom;6. African Cancer Registry Network, 267 Banbury Road, Oxford OX2 7HT, United Kingdom;1. Department of Otolaryngology Head & Neck Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China;2. Department of Otorhinolaryngology, Hu County People’s Hospital, Xi’an 710300, China;3. Department of Otolaryngology Head & Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China |
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| Abstract: | The Epstein-Barr virus (EBV) is an oncogene virus which is widely spread in the human populations. Following infection, EBV establishes a latent infection which allows its persistence during the entire life of the infected host. Most often viral persistence is asymptomatic. Nevertheless Epstein-Barr virus is also associated with various malignancies of epithelial (nasopharygeal carcinoma) and B-cell origin (Burkitt's lymphoma, B-cell lymphomas and lymphoproliferative diseases of immunocompromised patients). An important part of our current knowledge provides from studies which have been conducted on EBV-infected cell lines. This review aimed at presenting these data and will most especially stress on various aspects of the biological cycle of the virus and its ability to transform cells. |
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