| Synthesis of the chiral spiro-cyclopropane derivative and its crystal structure |
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| 作者姓名： | ZHANG Xiyun CHEN Qinghua |
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| 作者单位： | Department of Chemistry, Beijing Normal University, Beijing 100875, China,Department of Chemistry, Beijing Normal University, Beijing 100875, China |
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| 摘 要： | The spiro l-bromo-4-/-mentholoxy-5-oxo-6-oxabicyclo3. 1.0] hexane-2, 3'-(4'-ethoxy-5'-/-men-thyloxybutyrolactone)] 4 was synthesized via the tandem double Michael addition/internal nucleophilic substitution of chiral synthon 1, 5-/-menthyloxy- 3-bromo-2 (5H)-furanone, with nucleophilic ethanol. The two synthetic routes to compound 4 and its analytical data of structure are reported. The absolute configuration of 4 was determined by X-ray crystallography. These results provide a valuable strategy for synthesizing some biologically active molecules.
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| 关 键 词： | tandem asymmetric reaction biological activity spiro-cyclicpropane derivative containing multichiral centers. |
Synthesis of the chiral spiro-cyclopropane derivative and its crystal structure |
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| ZHANG Xiyun,CHEN Qinghua.Synthesis of the chiral spiro-cyclopropane derivative and its crystal structure[J].Progress in Natural Science,2000,10(11):867-873. |
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| Authors: | ZHANG Xiyun CHEN Qinghua |
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| Institution: | Department of Chemistry, Beijing Normal University, Beijing 100875, China,Department of Chemistry, Beijing Normal University, Beijing 100875, China |
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| Abstract: | The spiro l-bromo-4-/-mentholoxy-5-oxo-6-oxabicyclo3. 1.0] hexane-2, 3'-(4'-ethoxy-5'-/-men-thyloxybutyrolactone)] 4 was synthesized via the tandem double Michael addition/internal nucleophilic substitution of chiral synthon 1, 5-/-menthyloxy- 3-bromo-2 (5H)-furanone, with nucleophilic ethanol. The two synthetic routes to compound 4 and its analytical data of structure are reported. The absolute configuration of 4 was determined by X-ray crystallography. These results provide a valuable strategy for synthesizing some biologically active molecules. |
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| Keywords: | tandem asymmetric reaction biological activity spiro-cyclicpropane derivative containing multichiral centers |
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