| In vivo Dynamic Studies of Brain Metabolism |
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| 作者姓名： | 罗雪春 蒋玉凤 张日清 |
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| 作者单位： | [1]Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China [2]State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China [3]Department of Pathology, Beijing University of Chinese-Medicine, Beijing 100029, China |
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| 基金项目： | Supported by the Key Technologies Research and DevelopmentProgram of the Ninth Five-Year Plan of China （No.96-906-09-03） and the “985” Fund of Tsinghua University |
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| 摘 要： | Nuclear magnetic resonance （NMR） can noninvasively monitor intracellular concentrations and kinetic properties of numerous inorganic and organic compounds. A ^31p NMR surface coil was used in vivo to dynamically measure phosphocreatine （PCr）, adenosine triphosphate （ATP）, and intracellular inorganic phosphate （Pi） levels in mouse brain during ischemia-reperfusion to study the damage of cerebral tissues caused by ischemia and effects of herbs on cerebral energy metabolism during ischemia-reperfusion. The study provides dynamic brain energy metabolism data during different periods. The data show that some herbs more rapidly increase the PCr level during the recovery phase than in the control group.
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| 关 键 词： | 大脑 新陈代谢 动态特性 核磁共振 脑细胞 |
| 收稿时间： | 2004-12-17 |
| 修稿时间： | 2004-12-17 |
In vivo Dynamic Studies of Brain Metabolism |
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| Xuechun Luo, ê&#x;, Yufeng Jiang, &#x;,Riqing Zhang, .In vivo Dynamic Studies of Brain Metabolism[J].Tsinghua Science and Technology,2005,10(4):496-498. |
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| Authors: | Xuechun Luo ê&#x; Yufeng Jiang &#x; Riqing Zhang |
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| Institution: | aDepartment of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China;bState Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China;cDepartment of Pathology, Beijing University of Chinese Medicine, Beijing 100029, China |
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| Abstract: | Nuclear magnetic resonance (NMR) can noninvasively monitor intracellular concentrations and kinetic properties of numerous inorganic and organic compounds. A 31P NMR surface coil was used in vivo to dynamically measure phosphocreatine (PCr), adenosine triphosphate (ATP), and intracellular inorganic phosphate (Pi) levels in mouse brain during ischemia-reperfusion to study the damage of cerebral tissues caused by ischemia and effects of herbs on cerebral energy metabolism during ischemia-reperfusion. The study provides dynamic brain energy metabolism data during different periods. The data show that some herbs more rapidly increase the PCr level during the recovery phase than in the control group. |
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| Keywords: | nuclear magnetic resonance (NMR) surface coil ischemia-reperfusion herbs |
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