Baluchistine,a new bisbenzylisoquinoline alkaloid |
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| Authors: | G. A. Miana J. E. Foy R. D. Minard M. Shamma |
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| Affiliation: | (1) Department of Pharmacy, Gomal University, Dera Ismail Khan, N.W.F.P., Pakistan;(2) Department of Chemistry, Pennsylvania State University, 16802 University Park, Pennsylvania, USA |
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| Abstract: | Summary The new phenolic bisbenzylisoquinoline alkaloid (+)-baluchistine, found inBerberis baluchistanica Ahrendt (Berberidaceae), has been assigned structure1. O-Methylation using ethereal diazomethane yields (+)-obaberine (2). Baluchistine is the 1 alkaloid of the oxyacanthine-berbamine group to incroporate a free phenolic function at C-6.this project was supported by NIH research grant CA-11450, awarded by the National Cancer Institute, PHS/DHEW. |
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