| 盐酸舒托必利的合成 |
| |
| 引用本文： | 朱占元,丁爱忠,牟玲.盐酸舒托必利的合成[J].北京工商大学学报(自然科学版),2003,21(3):21-22. |
| |
| 作者姓名： | 朱占元 丁爱忠 牟玲 |
| |
| 作者单位： | 江苏帝益药业有限公司,江苏,淮安,223002 |
| |
| 摘 要： | 以2-甲氧基-5-乙磺酰基苯甲酸为原料,合成了抗精神病药盐酸舒托必利。首先将2-甲氧基-5-乙磺酰基苯甲酸用甲醇酯化,制得2-甲氧基-5-乙磺酰基苯甲酸甲酯,产物与N-乙基-2-氨甲基四氢吡咯烷进行缩合反应得舒托必利,直接用浓盐酸成盐得盐酸舒托必利。合成路线工艺简便,条件温和,总收率57.5％。
|
| 关 键 词： | 盐酸舒托必利 新药 合成 |
| 文章编号： | 1671-1513(2003)03-0021-02 |
| 修稿时间： | 2002年3月15日 |
SYNTHESIS OF SULTOPRIDE HYDROCHLORIDE |
| |
| ZHU Zhan-yuan,DING Ai-zhong,MOU Ling.SYNTHESIS OF SULTOPRIDE HYDROCHLORIDE[J].Journal of Beijing Technology and Business University:Natural Science Edition,2003,21(3):21-22. |
| |
| Authors: | ZHU Zhan-yuan DING Ai-zhong MOU Ling |
| |
| Abstract: | Sultopride Hydrochloride which is an important antipsychotic drug , was Synthesized from 2-methoxy-5-ethylsulfonyl benzoic acid . The procedure involved three steps. Firstly, 2-methoxy-5-ethylsulfonyl benzoic acid was esterified with methyl alcohol to produce 2-methoxy-5-ethylsulfonyl benzoic acid methylester; then, condensation with N-ethyl-2-aminomethyl pyrrolidine, acidifying with hydrochloric acid(37%). The conditions of all reactions were mild and the processes were convenient; the total yield was above 57. 5%. |
| |
| Keywords: | sultopride Hydrochloride new drug synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
