油橄榄叶提取物对铅中毒小鼠血液生化指标的影响

探讨油橄榄叶提取物对铅中毒小鼠血液组织生化指标的干预作用．选健康小鼠，每日灌服醋酸铅溶液的同时灌服不同剂量的油橄榄叶提取物，连续用药30d，检测血液中各项生化指标．结果表明，橄榄叶提取物对铅中毒小鼠的血液有显著影响．与模型对照组相比，小鼠灌服油橄榄叶提取物后血中铅的质量含量下降，白细胞、淋巴细胞、中性粒细胞数目显著降低，血红蛋白质量含量和血小板的数目等指标、血清中一氧化氮合酶（NOS）和超氧化物歧化酶（SOD）的活性及一氧化氮（N0）的质量含量均升高，丙二醛（MDA）的质量含量降低．橄榄叶提取物对铅中毒小鼠有一定的疗效，能降低血中铅的质量含量，可改善小鼠血液生化指标，提高抗氧化能力．

Effects of Olive Leaf Extract on Biochemical Indexes of Blood in Mice With Lead Poisoned

To study the effects of olive leaf extract(OLE) on biochemical indexes of blood in mice with lead poisoned.The health mice were chosen and daily intragastric administration with lead acetate and with different dose of OLE for 30 days.The biochemical indexes of blood were measured.OLE impacted on the blood Pb level and significantly impacted on the number of cells like leucocytes,lymphocytes and neutrophils with significantly decreased indexes compared with model group.It also impacted on the hemoglobin concentration and number of platelet with significantly increased indexes.Administration of OLE increased the activities of nitricoxide synthase(NOS),superoxide dismutase(SOD) and nitric-oxide(NO) content,while malondialdehyde(MDA) content decreased.OLE has significant effects on the accelerating lead excretion,improving the biochemical indexes of blood and its antioxidant function.