Hydroxydihydroergosine,a new ergot alkaloid analogue from directed biosynthesis bySphacelia sorghi |
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| Authors: | S M Atwell P G Mantle |
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| Institution: | (1) Biochemistry Department, Imperial College of Science and Technology, SW7 2AY London, (England) |
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| Abstract: | Summary A new ergot alkaloid, 9 -hydroxydihydroergosine, has been produced by axenic cultures ofSphacelia sorghi to which 4-hydroxy-proline was added when biomass accumulation was complete. Evidence for a lack of biosynthetic specificity for the first, second and third amino acid in cyclic tripeptide alkaloids has now been found amongst ergot fungi.Supported by the Science Research Council and Roche Products Ltd. |
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