| 聚N-(2-羟丙基)甲基丙烯酰胺-美他沙酮前药的合成与表征 |
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| 引用本文： | 周永柱,张娟,刘毅锋,谢俊.聚N-(2-羟丙基)甲基丙烯酰胺-美他沙酮前药的合成与表征[J].西北大学学报,2010(5). |
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| 作者姓名： | 周永柱 张娟 刘毅锋 谢俊 |
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| 作者单位： | 西北大学应用化学研究所; |
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| 基金项目： | 陕西省教育厅专项基金资助项目(09JK791) |
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| 摘 要： | 目的研究聚N-(2-羟丙基)甲基丙烯酰胺-美他沙酮(PHPMA-Met)前药的合成方法。方法以偶氮二异丁腈(AIBN)为引发剂,通过自由基反应,聚合得到PHPMA,进而以氯乙酰氯为连接基,与Met反应,合成了PHPMA-Met,并对产物进行了元素、红外、差示扫描量热分析鉴定和表征。结果 Met在前药中的含量大于15%。结论该制备方法简单,条件温和,具有很好的应用前景。
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| 关 键 词： | N-(2-羟丙基)甲基丙烯酰胺 前药 自由基反应 |
Synthesis and characterization of PHPMA-Met macromolecule prodrug |
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| ZHOU Yong-zhu,ZHANG Juan,LIU Yi-feng,XIE Jun.Synthesis and characterization of PHPMA-Met macromolecule prodrug[J].Journal of Northwest University(Natural Science Edition),2010(5). |
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| Authors: | ZHOU Yong-zhu ZHANG Juan LIU Yi-feng XIE Jun |
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| Abstract: | Aim To report a method for synthesis of poly N-(2-hydroxypropyl) methacrylamide-Met(PHPMA-Met)macromolecule prodrug.Methods With AIBN as initiator,Polymerization of PHPMA is synthesized with monomer HPMA by radical reaction;then PHPMA-Met is synthesized thorugh using the reaction of PHPMA and Met by chloroacetyl chloride as connect the base.The products are characteriized by FTIR,elementary analysis and DSC.Results The content of Met in the prodrug is more than 15%.Conclusion The macromolecular prodrug prep... |
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| Keywords: | N-(2-hydroxypropyl) methacrylamide prodrug radical reaction |
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