Effects of sequential periods of intracranial hypertension on lung fluid balance

Summary Pulmonary hemodynamics and fluid and protein exchange were examined in dogs subjected to three successive periods of intracranial hypertension. Results indicate that the alteration in lung fluid balance is due to increased microvascular surface area following capillary recruitment. The relationship to the mechanism of neurogenic pulmonary edema is discussed.Acknowledgments. Supported in part by grants 79-N17, 80-N105 and 82-N136 from the California Affiliate of the American Heart Association, by a grant from the Strobel Medical Research fund of the American Lung Association of San Francisco and by USPHS GMO7416-2 traineeship (TAJ). The authors thank L. Blount, E. Blount and J. Wong for their assistance.