| An integrative model and analysis of cell cycle in fission yeast |
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| 引用本文： | TENG Hu HUANG Xun XIU Zhilong FENG Enmin. An integrative model and analysis of cell cycle in fission yeast[J]. 科学通报(英文版), 2005, 50(17): 1896-1903. DOI: 10.1360/982005-480 |
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| 作者姓名： | TENG Hu HUANG Xun XIU Zhilong FENG Enmin |
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| 作者单位： | [1]Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China [2]Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, China |
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| 摘 要： | Cell cycle is a programmed process, during which a cell proliferates to two daughter cells. The eukaryotic or-ganisms share the same characters, such as four cycle phases G1, S, G2 and M, the evolutionally conserved cell cycle proteins and its dependent kinases, and the check-points mechanism[1,2]. Due to the different functions and the complicated interactions of these proteins involved in cell cycle, it is very difficult to understand the regulatory mechanism of cell cycle in a whole sense …
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| 关 键 词： | 细胞循环 裂变酵母 数学模型 蛋白质 交互网络 |
| 收稿时间： | 2005-03-31 |
| 修稿时间： | 2005-03-312005-06-29 |
An integrative model and analysis of cell cycle in fission yeast |
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| Teng Hu,Huang Xun,Xiu Zhilong,Feng Enmin. An integrative model and analysis of cell cycle in fission yeast[J]. Chinese science bulletin, 2005, 50(17): 1896-1903. DOI: 10.1360/982005-480 |
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| Authors: | Teng Hu Huang Xun Xiu Zhilong Feng Enmin |
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| Affiliation: | TENG Hu1, HUANG Xun1, XIU Zhilong1 & FENG Enmin2 1. Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China; 2. Department of Applied Mathematics, Dalian University of Technology, Dalian 116024, China |
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| Abstract: | According to the recent investigation on cell cycle of fission yeast, a mathematical dynamic model is formulated. Four cyclins, e.g. Pucl, Cig1, Cig2 and Cdc13, are investigated here. The interacting networks between the cyclins and the process of cell cycle are mathematically described. The functions of these cyclins are particularly analyzed. Comparison among different mutants indicates that the cyclins play an important role in cell cycle. |
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| Keywords: | cell cycle fission yeast mathematic modeling protein interaction networks system biology. |
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