Determination of adhesive rate constant in normal and neoplastic homogeneic cells |
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| Authors: | P Pippia A Cogoli M Gaias G Piras G Ivaldi |
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| Institution: | (1) Istituto di Fisiologia Generale, Università di Sassari, Via Muroni 25, I-07100 Sassari, (Italy);(2) Laboratorium für Biochemie, ETH Zentrum, CH-8006 Zürich, (Switzerland);(3) Cattedra di Fisiologia Generale, Facoltà di Farmacia, Università di Genova, I-16100 Genova, (Italy) |
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| Abstract: | Summary The adhesive rate constant (ARC) of neoplastic SGS-2 cells which have a low contact inhibition, is remarkably higher than that of normal homogeneic fibroblasts. This is in contrast with the mutual adhesion theory which states that the loss of contact inhibition is strictly related to the loss of cell recognition and consequently to the loss of cell adhesion capacity.This research was supported in part by the Italian CNR Rome, grant No. 79.00955.04 and in part by the Swiss National Science Foundation, Berne, grant No. 3.499.079. The skilful technical assistance of Mrs Mirjam Valluchi is gratefully acknowledged. |
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