| 环孢素A药物质量浓度监测对患者早期移植肾功能的影响 |
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| 引用本文： | 李路玢,何晓敏,张清.环孢素A药物质量浓度监测对患者早期移植肾功能的影响[J].暨南大学学报,2009,30(2). |
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| 作者姓名： | 李路玢 何晓敏 张清 |
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| 作者单位： | 1. 暨南大学附属第一医院药剂科,广东,广州,510630
2. 暨南大学附属第一医院肾移植科,广东,广州,510630 |
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| 摘 要： | 目的:通过监测环孢素A的血药质量浓度,来判断和调整肾移植术后服用环孢素A(CsA)的有效剂量,为临床减少并发症提供参考.方法:采用免疫荧光偏振TDX法,测定286例肾移植术后受者全血CsA质量浓度,其中164例监测CsA谷值质量浓度(Co组),122例监测CsA峰值质量浓度(C2组).计算各自的药代动力学参数,分析两组CsA质量浓度测定值与肾移植功能状况及相关临床资料的关系.结果:两组出现急性排斥反应的发生率,Co组明显高于C2组,两组存在显著差异(P＞0.05),但两组在药物性肝、肾中毒及肺感染的发生率方面比较均未见显著差异(P＜0.05).结论:对CsA峰值质量浓度进行药代动力学的监测,可以较准确反映肾移植受者的药物剂量,尤其在监控急性排斥反应方面意义较大,同时也可减少CsA肾中毒的危险.
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| 关 键 词： | 环孢素A 药物监测 肾移植 |
Influence of cyclosporine pharmacokinetics on the kidney function of recipients at early stage after operation |
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| LI Lu-fen,HE Xiao-min,ZHANG Qing.Influence of cyclosporine pharmacokinetics on the kidney function of recipients at early stage after operation[J].Journal of Jinan University(Natural Science & Medicine Edition),2009,30(2). |
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| Authors: | LI Lu-fen HE Xiao-min ZHANG Qing |
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| Institution: | 1.Department of Pharmaceutics;2.Department of Kidney Transplantation;the First Affiliated Hospital;Jinan University;Guangzhou 510630;China |
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| Abstract: | Aim: To explore the clinical effective and safe concentration of cyclosporine(CsA) in kidney transplant recipients.Methods: the CsA blood concentrations in 286 cases were measured by fluorescence polarization immunoassay(TDX) method: 164 cases were monitored Co level(serve as group Co),122 cases were monitored C2 level(serve as group C2).The clinical dates including the incidence rate of renal function after transplant,acute rejection,liver and kidney intoxication of CsA,pneumonia were retrospectively analy... |
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| Keywords: | cyclosporine A drug monitoring kidney transplantation |
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