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| Silk Fibroin-modified Poly（butadiene） urethane Films and Their Effects on Fibroblast Viability | |
| 引用本文： | 孙东豪,吴微宇,李明忠,白伦,盛伟华. Silk Fibroin-modified Poly（butadiene） urethane Films and Their Effects on Fibroblast Viability[J]. 东华大学学报(英文版), 2008, 25(6): 680-685 |
| 作者姓名： | 孙东豪 吴微宇 李明忠 白伦 盛伟华 |
| 作者单位： | College of Chemistry，Chemical Engineering and Materials Science，Soochow University，College of Textile and Clothing Technology，Soochow University，College of Medicine，Soochow University |
| 基金项目： | 国家重点基础研究发展规划(973计划) |
| 摘 要： | Surface-modified poly（butadiene）urethane （PBTU） films with silk fibroin （SF） were prepared by simple chemical method under the normal temperature. The physical properties and biological behaviour of the SF-modified PBTU film were evaluated. The results showed that the SF-modified PBTU films kept the tenacity and pliability very well, and could overcome rigid and brittle weaks of silk fibroin films. The morphology of SF in the PBTU film was dendritic aggregations, and the water-contact angle measurement indicated that the surface hydrophilicity of modified films was apparently enhanced. The biocompatibility of PBTU films was improved due to the change of surface components. The degree of platelet adhesion and the cell viability of rat embryo dermal fibroblasts seeded on PBTU films, SF films, and SF-modified PBTU films were measured by counting platelets before and after they contacted the films and MTT assay, respectively. The results indicated that platelet adhesion resistance and cell viability on the modified film were greatly superior to those on the PBTU film and the compound interface had good stability in the air. |
| 关 键 词： | 皮肤成纤维细胞 表面改性 细胞活力 丝素蛋白 聚氨酯膜 丁二烯 科幻电影 血小板粘附 |
Silk Fibroin-modified Poly (butadiene) urethane Films and Their Effects on Fibroblast Viability |
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| SUN Dong-hao,WU Zheng-yu,LI Ming-zhong,BAI Lun,SHENG Wei-hua. Silk Fibroin-modified Poly (butadiene) urethane Films and Their Effects on Fibroblast Viability[J]. Journal of Donghua University, 2008, 25(6): 680-685 | |
| Authors: | SUN Dong-hao WU Zheng-yu LI Ming-zhong BAI Lun SHENG Wei-hua |
| Affiliation: | 1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215021, China 2. College of Textile and Clothing Technology, Soochow University, Suzhou 215021, China 3. College of Medicine, Soochow University, Suzhou 215021, China |
| Abstract: | Surface-modified poly(butadiene)urethane (PBTU) films with silk fibroin (SF) were prepared by simple chemical method under the normal temperature. The physical properties and biological behaviour of the SF-modified PBTU film were evaluated. The results showed that the SF-modified PBTU films kept the tenacity and pliability very well, and could overcome rigid and brittle weaks of silk fibroin films. The morphology of SF in the PBTU film was dendritic aggregations, and the water-contact angle measurement indicated that the surface hydrophilicity of modified films was apparently enhanced. The biocompatibility of PBTU films was improved due to the change of surface components. The degree of platelet adhesion and the cell viability of rat embryo dermal fibroblasts seeded on PBTU films, SF films, and SF-modified PBTU films were measured by counting platelets before and after they contacted the films and MTT assay, respectively. The results indicated that platelet adhesion resistance and cell viability on the modified film were greatly superior to those on the PBTU film and the compound interface had good stability in the air. |
| Keywords: | poly(butadiene)urethane silk fibroin modification fibroblast platelet adhesion |
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