成人型弥漫性胶质瘤的分子分型研究进展

从2007年世界卫生组织的分型指南出发，综述了近20年来成人型弥漫性胶质瘤的分型诊断进展.胶质瘤分型诊断理论的重要变化，是从基于临床和组织学特征的组织学分型向结合细胞生理学分子特征的分子分型的转变.若干胶质瘤分子、特征核型的发现促成了分型理论向疾病本质的深化.在此之上，基于脑发育模型的分型，而非基于组织学的形态特征的分型，有望成为胶质瘤分型的方向.

The molecular classification of adult diffuse glioma: a review

Starting from the Classification Instruction of 2007 World Health Organization, this work review developments in molecular classification of adult diffuse glioma in the past two decades．A significant change in the classification scheme of glioma occurred: from clinical and histological classification to molecular classification combined with physiology．Some of the discoveries in molecular characteristics of glioma and karyotype features have prompted the classification schemes to deepen into the nature of glioma．On top of this, the classification scheme based on models of development of brain, rather than classification scheme based on histology, will be the future direction of glioma classification．