Monoamine oxidase activities in human brain microvessels |
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| Authors: | D H Haenick R K Ladman Janet Weiss D H Boehme W H Vogel |
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| Institution: | (1) Department of Pharmacology, Thomas Jefferson University, 19107 Philadelphia, PA, USA;(2) Veterans Administration Hospital, 07019 East Orange, NJ, USA;(3) Thomas Jefferson University, Philadelphia |
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| Abstract: | Summary Microvessels can be easily isolated from human brain samples obtained at autopsy. Human frontal cortex MAO type A and B activities are similar in microvessel and microvessel-free preparations. In microvessels, enzyme activities and the ratio of MAO type A to type B vary among the areas studied and could selectively regulate the passage of certain amines through the blood vessel wall.Acknowledgment. The technical assistance of N. Gentile and the financial support by NIMH grant MH31156 is gratefully acknowledged. |
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