Neuronal growth cone migration |
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| Authors: | S H Devoto |
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| Institution: | (1) Laboratory of Neurobiology, The Rockefeller University, 10021 New York, New York, USA;(2) Present address: Department of Microbiology/Immunology, Duke University Medical Center, P.O. Box 3054, 27710 Durham, NC, USA |
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| Abstract: | Summary The neuronal growth cone is a semi-autonomous portion of the developing neuron that is highly specialized for motile activity. Migrating neurons may share some features with neuronal growth cones. I review some of what has been learned about growth cone initiation, the differentiation of axons and dendrites, the role of the cytoskeleton in motility, the movements of membrane vesicles, the factors regulating the rate and direction of growth cone movement, and the further differentiation of growth cones as they enter the target area and initiate synaptogenesis. Where appropriate, I draw comparisons to what is known about the migration of neurons. |
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| Keywords: | Growth cones neural development cell motility cytoskeleton actin synapse formation |
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