Functional interactions of protein kinase A and C in signalling networks: a recapitulation |
| |
Authors: | E. Maioli C. Torricelli V. Fortino |
| |
Affiliation: | (1) Department of Physiology, University of Siena, via Aldo Moro 8, 53100 Siena, Italy |
| |
Abstract: | On the basis of evidence collected from the literature, we propose a general model by which protein kinase (PK) A and the different PKC isoforms can inversely affect cell growth. Molecular switches, which are able to direct the signal towards antiproliferative or mitogenic pathways, are the different isoforms of Raf and PKC. Conflicting data are also reported and discussed in an attempt to reconcile them. Received 10 November 2005; received after revision 28 December 2005; accepted 3 January 2006 |
| |
Keywords: | PKA Raf-1 Raf B RKIP PKC isoforms ERKs p21 |
本文献已被 PubMed SpringerLink 等数据库收录! |