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Changes of X-prolyl dipeptidyl-aminopeptidase activity in developing rat brain
Authors:T Kato  T Hama  T Nagatsu  H Kuzuya  S Sakakibara
Institution:(1) Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, 227 Yokohama, Japan;(2) Department of Biochemistry, Tohoku Dental University, 963 Koriyama, Fukushima, Japan;(3) Peptide Institute, Protein Research Foundation, 562 Minoh, Osaka, Japan
Abstract:Summary We found X-prolyl dipeptidyl-aminopeptidase activity in rat brain and examined the developmental changes at various ages. The total enzyme activity per brain increased until 4 weeks of age, and then decreased during maturation. Specific activity in young rat brain was higher than that in adult rat brain. The properties of the brain enzyme were different from those of pituitary and other tissues.
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