| IL-21免疫调节HIV/SIV感染者T淋巴细胞的研究进展 |
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| 引用本文： | 赵长城,魏强.IL-21免疫调节HIV/SIV感染者T淋巴细胞的研究进展[J].实验动物科学,2012,29(3):53-56. |
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| 作者姓名： | 赵长城 魏强 |
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| 作者单位： | 中国医学科学院医学实验动物研究所,卫生部人类疾病比较医学重点实验室,国家中医药管理局人类疾病动物模型三级实验室,北京100021 |
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| 基金项目： | 中央级公益性科研院所基本科研业务费项目(DWS201015)资助 |
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| 摘 要： | 白细胞介素21（IL-21）是一种新近发现的、具有免疫调节作用的细胞因子,可通过多途径影响CD4＋T细胞的应答,增强CD8＋T细胞介导的抗HIV/SIV作用,具有潜在的抗HIV/SIV的临床应用前景。血清IL-21水平测定有望作为确定HIV感染者AIDS病程以及HIV感染者抗病毒治疗反应的重要免疫学参数。近年来关于IL-21免疫调节HIV/SIV感染者T淋巴细胞的研究日益增多,并取得了一些成果。
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| 关 键 词： | 白细胞介素-21 抗病毒 HIV/SIV T淋巴细胞 免疫调节 |
Advance on Immunoregulating Effect of IL-21 on HIV/SIV~+ T Lymphocyte |
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| ZHAO Chang-cheng
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WEI Qiang.Advance on Immunoregulating Effect of IL-21 on HIV/SIV~+ T Lymphocyte[J].Shiyan Dongwu Kexue,2012,29(3):53-56. |
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| Authors: | ZHAO Chang-cheng WEI Qiang |
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| Institution: | (Key Laboratory of Human Diseases Comparative Medicine,Ministry of Health;Institute of Medical Laboratory Animal Science,Chinese Academy of Medical Sciences;Key Laboratory of Human Diseases Animal Models, State administration of Traditional Chinese medicine,Beijing 100021,China) |
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| Abstract: | Interleukin 21 is a novel and immunoregulatory cytokine,and it affects CD4+ T cell response and enhances CD8+ T cell-induced anti-HIV/SIV activity through several pathways,therefore it is considered to be a potential biofactor for anti-HIV/SIV in the future.IL-21 levels from serum may serve as an important immune parameter for determining progression of HIV infection and the response to anti-retroviral therapy in HIV-infected treatment.During recent years,more and more researches on immunoregulating T lymphocyte effect of IL-21 increase,and some achievements have been achieved.The research advances were reviewed in this paper. |
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| Keywords: | interleukin 21 antivirus HIV/SIV T lymphocyte immunoregulation |
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