The c-mos proto-oncogene product is a cytostatic factor responsible for meiotic arrest in vertebrate eggs |
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Authors: | N Sagata N Watanabe G F Vande Woude Y Ikawa |
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Institution: | Tsukuba Science Center (RIKEN), Ibaraki, Japan. |
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Abstract: | The c-mos proto-oncogene product, pp39mos, is present in unfertilized Xenopus eggs, and disappears on fertilization. Microinjection of synthetic mos RNA into two-cell embryos induces cleavage arrest at metaphase. By contrast, egg cytosol extracts, when immunodepleted of endogenous pp39mos, lose their cleavage-arresting activity in injected embryos. These results demonstrate that Mos protein is the cytostatic factor CSF, long known as an endogenous meiotic inhibitor in vertebrate eggs. |
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