Effects of antithymic reticuloepithelial cells serum on the levels of circulating thymic factor and on the sensitivity to azathioprine of spleen spontaneous rosette-forming cells |
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| Authors: | E Garaci Vera del Gobbo Cristina Rinaldi-Garaci |
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| Institution: | (1) Present address: Institute of Microbiology, Catania University, I-95100 Catania, Italy;(2) Present address: Institute of General Biology dell' Università, Piazzale delle Scienze, I-00100 Roma, Italy |
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| Abstract: | Summary Swiss mice treated with an antithymic reticuloepithelial cells serum (ATRES) showed a drastic and prolonged depression of the serum thymic factor. A similar but less pronounced effect was also observed following the administration of the antithymocyte (ATS) and the antilymphocyte (ALS) sera. Conversely, the azathioprine sensitivity of spleen spontaneous rosette-forming cells was highly modified by the ATRES but not by the ATS or the ALS. The probable mechanisms of such effects are discussed. |
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