| 定量构效关系研究进展及其应用 |
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| 引用本文： | 安丽英,相玉红,张卓勇,胡文祥.定量构效关系研究进展及其应用[J].首都师范大学学报(自然科学版),2006,27(3):52-57. |
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| 作者姓名： | 安丽英 相玉红 张卓勇 胡文祥 |
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| 作者单位： | 首都师范大学化学系,北京,100037 |
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| 摘 要： | 定量构效关系是目前国际上一个比较活跃的研究领域.本文简要介绍了定量构效关系的发展历史及定量构效关系研究中常用方法等,其中较为详细地介绍了三维定量构效关系中广泛应用的CoMFA方法.综述了定量构效关系在环境污染物分析以及在农药、医药设计中的应用,并对定量构效关系研究的发展趋势进行了展望.
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| 关 键 词： | 定量构效关系 环境污染物分析 药物设计 综述 |
| 收稿时间： | 2005-10-27 |
| 修稿时间： | 2005年10月27 |
The New Advance and Applications of Quantitative Structure-Activity Relationship |
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| An Liying,Xiang Yuhong,Zhang Zhuoyong,Hu Wenxiang.The New Advance and Applications of Quantitative Structure-Activity Relationship[J].Journal of Capital Normal University(Natural Science Edition),2006,27(3):52-57. |
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| Authors: | An Liying Xiang Yuhong Zhang Zhuoyong Hu Wenxiang |
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| Institution: | Department of Chemistry, Capital Normal University, Beijing 100037 |
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| Abstract: | Quantitative Structure-Activity Relationship(QSAR) is now an internationally active research field.In this paper,the development and common methods of QSAR are briefly introduced CoMFA as a most popular method is introduced in detail.The Applications of QSAR in environmental pollutant analysis and drug design are reviewed and the prospect of QSAR is also forecasted. |
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| Keywords: | CoMFA |
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