Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis |
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Authors: | Franke Andre Balschun Tobias Karlsen Tom H Hedderich Jürgen May Sandra Lu Tim Schuldt Dörthe Nikolaus Susanna Rosenstiel Philip Krawczak Michael Schreiber Stefan |
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Affiliation: | Institute for Clinical Molecular Biology, Christian-Albrechts-University, D-24105 Kiel, Germany. |
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Abstract: | Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. |
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