Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease |
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| Authors: | Fisher Sheila A,Tremelling Mark,Anderson Carl A,Gwilliam Rhian,Bumpstead Suzannah,Prescott Natalie J,Nimmo Elaine R,Massey Dunecan,Berzuini Carlo,Johnson Christopher,Barrett Jeffrey C,Cummings Fraser R,Drummond Hazel,Lees Charlie W,Onnie Clive M,Hanson Catherine E,Blaszczyk Katarzyna,Inouye Mike,Ewels Philip,Ravindrarajah Radhi,Keniry Andrew,Hunt Sarah,Carter Martyn,Watkins Nick,Ouwehand Willem,Lewis Cathryn M,Cardon Lon Wellcome Trust Case Control Consortium,Lobo Alan,Forbes Alastair,Sanderson Jeremy,Jewell Derek P,Mansfield John C,Deloukas Panos,Mathew Christopher G,Parkes Miles |
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| Affiliation: | Department of Medical and Molecular Genetics, King's College London School of Medicine, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, UK. |
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| Abstract: | We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases. |
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