| 结核分枝杆菌的免疫机制及抗原研究进展 |
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| 引用本文： | 刘文,胡巍,王洪海.结核分枝杆菌的免疫机制及抗原研究进展[J].淄博学院学报(自然科学与工程版),2002(3):85-89. |
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| 作者姓名： | 刘文 胡巍 王洪海 |
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| 作者单位： | [1]复旦大学，上海２００４３３ [2]山东理工大学，山东淄博２５５０９１ |
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| 摘 要： | 结核分枝杆菌是一种胞内病原苗，在抗结核分枝杆菌感染中，活菌疫苗中的分泌蛋白起主要的免疫保护作用，它们激活宿主Ｔ细胞介导的细胞免疫，影响宿主免疫保护与病菌耐受性之间的不稳定平衡，决定宿主是否得病．结核分枝杆菌的特异性和保护性抗原的筛选为结核病的快速诊断及新型疫苗构建打下基础．
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| 关 键 词： | 结核分枝杆菌 免疫机制 抗原 研究进展 |
Advance for the Study on Immunological Mechanism and Antigen of Mycobacterium Tuberculosis |
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| LIU wen,HU Wei,WANG Hong-hai.Advance for the Study on Immunological Mechanism and Antigen of Mycobacterium Tuberculosis[J].Journal of Zibo University(Natural Sciences and Engineering),2002(3):85-89. |
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| Authors: | LIU wen HU Wei WANG Hong-hai |
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| Abstract: | M. tuberculosis is a facultative intracellular pathogen. Extracellular proteins of M. tuberculosis induce a strong T cell-mediated immune response. Cell mediated immunity (CMI) as opposed to humoral immunity play a dominant in host defense against M. tuberculosis. The identification of specific and protective antigens of M. tuberculosis can be applied in tuberculosis diagnosis and vaccine construction. |
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| Keywords: | Mycobacterium tuberculosis immunological mechanism antigen cell mediated-immunity |
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