Synthesis and antimutagenic effects of selena-morpholine hydrate |
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Authors: | Wu Jun Liu Xiu-fang Xu Han-sheng Ran Yong Wu Hui-qiong Cai Lian-hua |
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Institution: | (1) College of Chemistry and Environmental Science, Wuhan University, 430072 Wuhan, China;(2) Department of Environmental Toxicology, School of Public Health, Tongji Medical University, 430030 Wuhan, China |
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Abstract: | The synthesis of selenamorpholine hydrate was described and its antimutagenic effects were investigated by the Ames tests.
The results indicated that the mutation induced by the indirect mutagen 2-AF was inhibited obviously by selenamorpholine hydrate
at the dosage of Se 0.16∼100 μg/dish for 35.8%∼53.7% (TA97) and the mutation induced by direct mutagen Dexon was inhibited for 6.2%∼30.0% (TA97) and 2.3% ∼34.1% (TA100). The mutagenesis of the indirect mutagen cyclophosphamide was suppressed for 5.4%∼ 16.1% by selenamorpholine hydrate at
the dosage of Se 0.16∼100 μg/dish.
Foundation item: Hubei Provine Natural Science Foundation
Biography: WU Jun (1970-), female, lecture, Ph.D. |
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Keywords: | synthesis selenamorpholine hydrate Ames test antimutation |
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