A physical map of human chromosome 14 |
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Authors: | Brüls T Gyapay G Petit J L Artiguenave F Vico V Qin S Tin-Wollam A M Da Silva C Muselet D Mavel D Pelletier E Levy M Fujiyama A Matsuda F Wilson R Rowen L Hood L Weissenbach J Saurin W Heilig R |
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Institution: | Genoscope and CNRS UMR 8030, Evry, France. |
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Abstract: | We report the construction of a tiling path of around 650 clones covering more than 99% of human chromosome 14. Clone overlap information to assemble the map was derived by comparing fully sequenced clones with a database of clone end sequences (sequence tag connector strategy). We selected homogeneously distributed seed points using an auxiliary high-resolution radiation hybrid map comprising 1,895 distinct positions. The high long-range continuity and low redundancy of the tiling path indicates that the sequence tag connector approach compares favourably with alternative mapping strategies. |
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