中药及其活性成分对肿瘤相关调节性T细胞抑制作用研究

尽管只占外周CD4T淋巴细胞的10%,调节性T细胞(CD4~+ Foxp~(3+) regulatory T cells,Treg细胞)却是免疫系统不可缺少的重要组成部分,因为该群细胞对维持免疫系统内环境稳定及防止自身免疫反应至为关键。在肿瘤患者,Treg细胞大量积聚于肿瘤微环境中,强烈抑制机体对肿瘤的保护性免疫监视和对肿瘤的免疫反应,从而帮助肿瘤细胞发生免疫逃逸,促进肿瘤的发生和发展。目前的研究表明,中药可以通过减少Treg细胞的数量或比例、抑制Treg细胞的功能和相关细胞因子的产生以及转录因子的表达,从而抑制肿瘤的生长和转移。文章通过对有关文献的综述和分析,详细介绍了中药对肿瘤相关Treg细胞的作用及机制。

The research progress of inhibition of tumor-associated regulatory T cells by traditional Chinese medicine and its active ingredients#br#

Although only comprising ~10 % of peripheral CD4 T cells, CD4+Foxp3+ regulatory T cells (Treg cells) are an indispensable components of immune system, they played a crucial role in the maintenance of immune homeostasis and in the prevention of autoimmune responses. In the tumor patients, Treg cells accumulate in a large number in the tumor microenvironment, and potently inhibit the protective immune surveillance against tumor and anti-tumor immune responses. Thus, Treg cells help tumor immune evasion and promote the development and metastasis of tumors. Recently studies have shown that Chinese medicine can inhibit the growth and metastasis of tumor by decreasing the number or proportion of Tregcells, or by inhibiting Treg activity or their capacity to produce immunosuppressive cytokines or their Foxp3 expression. In this article, the relevant published studies are reviewed and analyzed, and the research progress regarding the effects and mechanisms of traditional Chinese medicine on tumor-associated Treg cells are introduced and discussed.