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Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis |
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| Authors: | van Es Michael A van Vught Paul W J Blauw Hylke M Franke Lude Saris Christiaan G J Van den Bosch Ludo de Jong Sonja W de Jong Vianney Baas Frank van't Slot Ruben Lemmens Robin Schelhaas Helenius J Birve Anna Sleegers Kristel Van Broeckhoven Christine Schymick Jennifer C Traynor Bryan J Wokke John H J Wijmenga Cisca Robberecht Wim Andersen Peter M Veldink Jan H Ophoff Roel A van den Berg Leonard H |
| Affiliation: | Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands. |
| Abstract: | We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies. |
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