布洛芬手性拆分分子印迹复合膜的制备与表征

以接枝环糊精的醋酸纤维素复合物为铸膜材料，S-布洛芬为印迹分子，采用相转化法制备了用于手性分离的分子印迹膜；用FT-IR和SEM测试手段对膜的化学组成和结构形态进行了表征；通过渗透实验考察了该分子印迹膜对外消旋布洛芬的手性拆分性能。结果表明在β-环糊精接枝率为29.01%（质量分数），模板分子浓度比为1∶10，铸膜液质量分数为12.5%的条件下，分子印迹膜对右旋布洛芬的分离因子可达2.09。

Preparation and evaluation of molecular imprinted composite membranes for chiral resolution of ibuprofen

Molecular imprinted membranes of S-ibuprofen were prepared by the phase inversion technique with cellulose acetate-β-cyclodextrin copolymer (P(CA-co -β-CD)). To characterize P(CA-co-β-CD), a biosensor was used to measure its grafting ratio, and P(CA-co-β-CD) polymers with different grafting ratios were used to prepare membranes. A copolymer-DMF solution with a S-ibuprofen template was coagulated in water at 20 ℃. Increasing P(CA-co-β-CD) grafting ratio resulted in an increase in S-ibuprofen recognition properties of the resulting membrane. The S-ibuprofen imprinted membrane prepared with P(CA-co-β-CD) showed good selectivity to S-ibuprofen. Surface and cross-section morphologies of the membranes were analyzed by scanning electron microscopy. High-performance liquid chromatography was used for the quantification of ibuprofen in the isolated fraction. Under the optimum conditions of β-CD grafting yield of 29.01% (mass fraction), polymer mass fraction of 12.5%, and a concentration ratio of CA to S-Ibu of 1∶10, the separation factor reached a maximum value of 2.09.