The glucose dependence of pancreatic endocrine responses to 2-deoxyglucose in the calf |
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Authors: | A V Edwards S R Bloom |
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Institution: | (1) Physiological Laboratory, Downing Street, CB2 3EG Cambridge, (England);(2) Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, W12 London, (England) |
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Abstract: | Summary The initial plasma glucose concentration of unanesthetized calves with cut splanchnic nerves, given 2-deoxyglucose (1.2 mmoles/kg, i.v.), was either lowered by prior starvation, or raised by a continuous infusion of exogenous glucose. Raising the initial plasma glucose concentration completely suppressed the release of pancreatic glucagon and pancreatic polypeptide but substantially enhanced the release of insulin in response to 2-deoxyglucose.This work has been supported by the Medical Research Council and the Leverhulme Trust. We are also indebted to Mr P.M.M. Bircham and Mr G.P. Macgregor for their skilled technical assistance. |
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