Transmural pressure as a determinant of basic intrinsic heart rate |
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Authors: | C. L. Pathak |
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Affiliation: | (1) Department of Physiology, Biophysics and Biochemistry, S. N. Medical College, Jodhpur, Rajasthan, India |
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Abstract: | Summary It was observed the heart rate was minimum at zero transmural pressure. The mean heart rate at zero transmural pressure was 23±5/min. This mean heart rate increased from 23±5/min to a peak value of 40±6/min (74% acceleratin) when the transmural pressure was raised from 0 to +4 mm Hg and to a similar peak value of 36±8/min (56% acceleration) when the transmural pressure was lowered from 0 to –4 mm Hg. The peak values attained at ±4 mm Hg were higly significant (p<0.001). It is concluded that the heart rate at zero transmural pressure represents the basic intrinsic pacemaker frequency independent of neural, humoral, thermal and haemodynamically induced mechanical influences. |
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