Effects of selective dopamine D1 and D2 antagonists on male rat sexual behavior |
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Authors: | S Ahlenius K Larsson |
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Institution: | (1) Present address: Department of Psychology, University of Göteborg, POB 14 158, S-400 20 Göteborg, (Sweden);(2) Department of Neuropharmacology, Astra Research Centre, S-151 85 Södertälje, (Sweden) |
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Abstract: | Summary The effects of selective dopamine (DA) D1 and D2 antagonists on male rat sexual behavior were investigated. The D1 antagonist (+)SCH-23390, 25–100 g kg–1 s.c. –20 min, and the D2 antagonist raclopride, 0.1–1.6 mg kg–1 s.c., –20 min, decreased both the number of mounts and intromissions preceding ejaculation. No statistically significant effects in the time up to ejaculation or in the time up to the first intromission were noted, whereas both compounds produced a statistically significant increase in the post-ejaculatory interval. The effect can generally be characterized as psychomotor inhibition, and no evidence was obtained for a specific role of DA D1 or D2 receptors in the mediation of male rat sexual behavior.The expert technical assistance of Ms Elisabeth Wallin is gratefully acknowledged. The figures were skilfully prepared by Ms Madelene Kröning at the Department of Psychology. This study received support from the Bank of Sweden tercentenary Foundation, The Swedish MRC and Wilhelm and Martina Lundgren Foundation. |
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Keywords: | Male rat sexual behavior dopamine |
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