Tumorigenic potential of endoperoxide analogs |
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| Authors: | A Lupulescu |
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| Institution: | (1) Medical Research Building, Wayne State University, 48201 Detroit, Michigan, USA |
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| Abstract: | Summary The endoperoxide analogs known as U-46619 and U-44069 significantly enhanced the carcinoma formation and cellular atypicality initiated by a chemical carcinogen in mice. Studies of DNA radioactivity demonstrated that endoperoxides exerted their cocarcinogenic action by stimulating DNA synthesis. Thus, they play an important role in tumor cell proliferation. |
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