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Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension |
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| Authors: | Pravenec Michal Churchill Paul C Churchill Monique C Viklicky Ondrej Kazdova Ludmila Aitman Timothy J Petretto Enrico Hubner Norbert Wallace Caroline A Zimdahl Heike Zidek Vaclav Landa Vladimir Dunbar Joseph Bidani Anil Griffin Karen Qi Nathan Maxova Martina Kren Vladimir Mlejnek Petr Wang Jiaming Kurtz Theodore W |
| Affiliation: | Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic. |
| Abstract: | To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension. |
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