| 新型吲哚席夫碱类化合物的合成及其抗菌活性研究 |
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| 引用本文： | 陈佰灵,刘兴利,赵志刚,石治川,郑礼婷.新型吲哚席夫碱类化合物的合成及其抗菌活性研究[J].西南民族大学学报(自然科学版),2016,42(2):170-175. |
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| 作者姓名： | 陈佰灵 刘兴利 赵志刚 石治川 郑礼婷 |
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| 作者单位： | 西南民族大学 化学与环境保护工程学院,西南民族大学 化学与环境保护工程学院,西南民族大学 化学与环境保护工程学院,西南民族大学 化学与环境保护工程学院,西南民族大学 化学与环境保护工程学院 |
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| 基金项目： | 四川省应用基础研究项目( 2012JY0028);西南民族大学研究生创新型科研项目(CX2014SZ44) |
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| 摘 要： | 以吲哚-3-甲酸甲酯为原料,通过偶联、肼解、消除等反应,合成了一系列具有对称结构的吲哚席夫碱衍生物,以期为新药筛选提供先导化合物.其结构均经~1H NMR,ESI-MS,IR及元素分析所证实.初步抗菌活性测定结果表明:化合物5e对枯草芽孢杆菌、金黄色葡萄球菌具有较强的抑菌效果;化合物5f对大肠杆菌的抑菌效果优于阿莫西林,对绿脓杆菌表现出与对照品阿莫西林相当的抑菌效果.
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| 关 键 词： | 吲哚 席夫碱 抗菌活性 |
| 收稿时间： | 2015/12/23 0:00:00 |
| 修稿时间： | 2016/3/7 0:00:00 |
Synthesis and antibacterial activities of novel indole Schiff base derivatives |
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| CHEN Bailing,LIU Xingli,ZHAO Zhigang,SHI Zhichuan and ZHENG Liting.Synthesis and antibacterial activities of novel indole Schiff base derivatives[J].Journal of Southwest University for Nationalities(Natural Science Edition),2016,42(2):170-175. |
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| Authors: | CHEN Bailing LIU Xingli ZHAO Zhigang SHI Zhichuan and ZHENG Liting |
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| Institution: | College of Chemistry and Environmental Protection Engineering,Southwest University for Nationalities,College of Chemistry and Environmental Protection Engineering,Southwest University for Nationalities,College of Chemistry and Environmental Protection Engineering,Southwest University for Nationalities,College of Chemistry and Environmental Protection Engineering,Southwest University for Nationalities,College of Chemistry and Environmental Protection Engineering,Southwest University for Nationalities |
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| Abstract: | A series of novel indole Schiff base derivatives were synthesized through coupling, hydrazine, and elimination reaction by using methyl indole-3-carboxylate as starting material. Their structures were elucidated by 1H NMR, ESI-MS spectra, IR and elemental analyses. The antibacterial activities of compounds were tested against two kinds of bacteria. The preliminary results indicated that compound 5e had potent inhibition activity against B. subtilis and S. aureus; Compound 5f showed higher antibacterial activity against E. coli and similar effect against P. aeruginosa than the standard reference drug (amoxicillin), respectively. |
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| Keywords: | indole Schiff base antibacterial activity |
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