蕨菜水提物对便秘小鼠的治疗作用

以硫糖铝致小鼠便秘为动物模型，常用临床药物福松（1.3 g/kg）处理为阳性对照，用小鼠排便和肠推进等试验方法探讨不同剂量（20，40，60 g/kg）的蕨菜水提物对便秘小鼠肠道蠕动能力的影响.试验结果表明，不同剂量的蕨菜水提物对便秘小鼠的小肠内容物推进率、首粒排便时间、粪便性状、4 h内排便粒数及其质量的影响均明显大于阴性；与阳性对照组对比，中剂量蕨菜水提物处理组在首粒排便时间、4 h内排便粒数及其质量等方面无明显差距，而高剂量蕨菜水提物处理组在首粒排便时间（（17.200 0±3.938 4）min）明显早于阳性组（（26.800 0±3.881 6）min）；在小肠内容物推进率方面，中、低剂量蕨菜水提物处理组（（34.000 5±6.057 5）%，（31.529 8±4.204 8）%）明显低于阳性组，而高剂量蕨菜水提物处理组（（41.948 1±4.219 4）%）与阳性组（（43.057 9±6.308 4）%）对比无显著差异.

Therapy Function of Aqueous Extract fromPteridium Aquilinumon Constipated Mice

Mice treated with sucralfate and Fosson were used as animal model to test the therapy function of aqueous extract of different concentration (20，40，60 g/kg) from fern on constipation.Results showed that,compared with the sucralfate-treated group (negative control)，the groups treated with fern water extract displayed obvious therapy improvement on intestine propulsion (SIP)，first defecation time，faeces properties and 4 h defecation grain number and mass.On the other hand，compared with the Fosson-therapy group (positive control)，the middle dose group demonstrated almost the same effect on constipation therapy；but as for first defecation time，the high dose group treated with aqueous extract (（17.200 0±3.938 4）min) was obviously sooner than the Fosson treated group (（26.800 0±3.881 6）min).And as for SIP，middle and low dose groups treated with fern aqueous extract (（34.000 5±6.057 5）%，（31.529 8±4.204 8）%) were obviously less than Fosson therapy group，but the high dose group (（41.9481±4.2194）%) showed almost no difference with Fosson therapy group（43.057 9±6.308 4）%).