野生东方田鼠的实验动物化及标准的建立

摘要: 东方田鼠是重要的实验动物资源之一，本文总结了本实验室过去十几年来对东方田鼠进行的实验动物化工作，包括生物学性状、建群者与群体的有效大小、驯养、驯化( 实验动物化) 及进化动力等方面的研究以及实验动物化结果的评估和地方标准的制定。展望了以新一代基因组测序技术为基础进行的抗性基因的寻找与新品系的精细培育新方法的摸索。

Wild Vole( Microtus fortis) Breeding as Laboratory Animal and Formulation of Local Standard

Abstract: Microtus fortis is one of the important resources as laboratory animal． In this review we summarized the work of breeding this animal from wild as laboratory animal in over the past ten years，the researches including of biological characteristics; the founder and effective size of the population; tameness and domestication ( breeding as laboratory animal) as well as the evolutionary force in this process． It was described that evaluation results of breeding as laboratory animal and formulation of local standard of this vole． New technology in finding the vole resistance gene of Schistosoma japonicum and new method of breeding strains will be expected under next-generation sequencing technique．