| 保肝Ⅰ号抗CCl4联合高脂饲料所致大鼠肝纤维化研究 |
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| 引用本文： | 孟薇薇,郭楠,林凡凯,赵海伟,邓玉林,戴荣继,陈艳,黄钰嵋,赵应红.保肝Ⅰ号抗CCl4联合高脂饲料所致大鼠肝纤维化研究[J].北京理工大学学报,2014,34(7):767-770. |
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| 作者姓名： | 孟薇薇 郭楠 林凡凯 赵海伟 邓玉林 戴荣继 陈艳 黄钰嵋 赵应红 |
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| 作者单位： | 北京理工大学生命学院,北京100081;北京理工亘元医药技术开发中心有限公司,北京100081;总参管理保障部中心门诊部,北京 100088;云南西双版纳州民族医药研究所,云南,景洪666100 |
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| 摘 要： | 研究保肝Ⅰ号（BGYH）对四氯化碳（CCl4）和高脂饮食联合诱导的大鼠肝纤维化的治疗作用. 40% CCl4-大豆油灌胃联合高脂饲料建立肝纤维化模型. 建模结束后模型组重新分组后用BGYH高、中、低剂量灌胃连续治疗17 d，进行肝脏病理和血清学检测. 检测结果表明BGYH能够减轻肝纤维化大鼠的脂肪变性和组织增生，降低肝纤维化模型大鼠血清中谷草转氨酶（AST）、谷丙转氨酶（ALT）含量，增加血清白蛋白（ALB），降低血清中透明质酸（HA），肝脏中羟脯氨酸（Hyp）和Ⅰ型胶原蛋白（Col Ⅰ）的. BGYH能够降低肝纤维化大鼠肝脏中的转氨酶水平，保护肝功能，减轻肝脏脂肪变性和纤维组织增生，具有显著抗肝纤维化的作用.
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| 关 键 词： | 保肝Ⅰ号 肝纤维化 四氯化碳 高脂饮食 |
| 收稿时间： | 2012/10/24 0:00:00 |
Effect of Baogan Yihao on Liver Fibrosis in Rats Induced by CCl4 and High-Fat Feeding |
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| MENG Wei-wei,GUO Nan,LIN Fan-kai,ZHAO Hai-wei,DENG Yu-lin,DAI Rong-ji,CHEN-Yan,HUANG Yu-mei and ZHAO Ying-hong.Effect of Baogan Yihao on Liver Fibrosis in Rats Induced by CCl4 and High-Fat Feeding[J].Journal of Beijing Institute of Technology(Natural Science Edition),2014,34(7):767-770. |
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| Authors: | MENG Wei-wei GUO Nan LIN Fan-kai ZHAO Hai-wei DENG Yu-lin DAI Rong-ji CHEN-Yan HUANG Yu-mei and ZHAO Ying-hong |
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| Institution: | 1.School of Life Science, Beijing Institute of Technology, Beijing 100081, China2.Beijing BIT & Gen Yuan Pharmaceutical R&D Co., LTD., Beijing 100081, China3.Department of Administration and Security of General Staff Headquarters, Beijing 100081, China4.Dai Medicine Research Institute of Xishuang Banna, Jinghong, Yunnan, 666100, China |
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| Abstract: | The effect of Baogan Yihao (BGYH) on hepatic fibrosis induced by carbon tetrachloride (CCl4) and high fat diet in rats was studied in this paper. Liver fibrosis was induced by CCl4-soybean and high fat diet for 6 weeks, and BGYH preparation (600 mg/mL, 300 mg/kg, 150 mg/kg) was administered to the model group for 17 days. The results show that BGYH relieved fatty degeneration and hyperplasia in liver. BGYH can lower aspartate aminotransferase (AST), alanine aminotransferase (ALT), increase serum albumin (ALB), reduce the hyaluronic acid (HA), hydroxyproline (Hyp) and type Ⅰ collagen protein (Col Ⅰ) in livers. BGYH can lower transaminase level, improve liver function, reduce steatosis and fibrosis in liver. Therefore, BGYH has a significant effect on liver fibrosis. |
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| Keywords: | Baogan Yihao hepatic fibrosis carbon tetrachloride high fat diet |
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