Peptidergic co-transmission inAplysia: Functional implications for rhythmic behaviors |
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Authors: | K R Weiss V B?ezina E C Cropper S L Hooper M W Miller W C Probst F S Vilim I Kupfermann |
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Institution: | (1) Department of Physiology and Biophysics, Mt. Sinai School of Medicine, 1 Gustave Levy Place, 10029 New York, New York, USA;(2) Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, 722 West 168th Street, 10032 New York, New York, USA |
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Abstract: | Despite their ubiquitous presence in the central and peripheral nervous systems, the behavioral functions of peptide co-transmitters remain to be elucidated. The marine molluscAplysia, whose simple nervous system facilitates the study of the neural basis of behavior, was used to investigate the role of peptidergic co-transmission in feeding behavior. Several novel modulatory neuropeptides were purified, and localized to identified cholinergic motorneurons. Physiological and biochemical studies demonstrated that these peptides are released when the motorneourons fire at frequencies that occur during normal behavior, and that the peptides modify the relationship between muscle contraction amplitude and relaxation rate so as to maintain optimal motor output when the intensity and frequency of feeding behavior change. |
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Keywords: | Aplysia co-transmission modulation motorneuron muscle peptide |
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