Effects of 18-hydroxydeoxycorticosterone on central nervous system excitability |
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Authors: | B Dubrovsky J Illes M K Birmingham |
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Institution: | (1) Department of Psychiatry and Psychology, McGill University, H3A 1A1 Montreal, Quebec, Canada |
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Abstract: | Summary The effects of 18-hydroxydeoxycorticosterone (18-OH-DOC) on central nervous system excitability were studied in adrenalectomized rats. Sixty-four evoked potentials (EP) recorded from the pontine reticular formation were averaged before and after the injection of vehicle and hormone. 750 g of 18-OH-DOC dissolved in 0.5 ml of a 4 1 saline Cremophor-EL solution were injected i.v. A decrease of 55.7±6.1% in the amplitude of the EPs was observed with the hormone 16.3 min±2.7 (SE) after injection. Amplitude values returned to baseline levels 38 min±6.8 (SE) after injection. The secretion of 18-OH-DOC is greatly increased by ACTH and might modulate central nervous system function. |
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Keywords: | 18-OH-DOC brain excitability |
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