The action of the peptidoleukotriene LTD4 on intracellular calcium in rat mesangial cells |
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Authors: | M. Ochsner |
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Affiliation: | (1) Physics Department, Ciba-Geigy Ltd., CH-4002 Basle, (Switzerland) |
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Abstract: | The dose-dependent effect of CGP 45715A on the LTD4-induced Ca2+ response of glomerular mesangial cells has been studied. Our results demonstrate that the LTD4-dependent increase in the cytosolic Ca2+ concentration primarily involves an InsP3-mediated release of Ca2+ from intracellular storage sites and to a minor extent an enhanced influx of Ca2+ through receptor-operated Ca2+ channels located in the plasma membrane. The action of CGP 45715A on the Ca2+ response is an inhibitory one and is convincingly explained by a displacement of LTD4 from its receptor site(s). The contractile effect of LTD4 on pulmonary smooth muscle is proposed to be mainly caused by a receptor-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. |
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Keywords: | Asthma LTD4 CGP 45715A LTD4-receptor antagonist cytosolic Ca2+ transient |
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