大鼠小肠对葛根素吸收的动力学研究

采用在大鼠小肠内吸收药物的方法，对葛根素的肠吸收动力学进行了研究。利用UV双波长等吸收消去法测定小肠循环液中葛根素的含量，结果表明，对于50、100和200 μg/mL质量浓度的葛根素，在小肠内循环4h后相应的药物吸收速率常数（Ka）分别为0.021、0.028 和0.020 h-1，吸收率（Pa）分别为19.28%、21.78%和16.98%，在不同浓度下葛根素的吸收速率常数无显著差异（显著性水平因子P>0.05），该药物在肠道内的吸收呈现一级吸收动力学过程，其吸收机制为被动扩散。

The absorption of puerarin in rats' intestines

Absorption kinetics of puerarin in rats` intestines was studied. Puerarin in small intestinal solutions were determined by dual-λ UV. Puerarin solutions were circulated for 4 hours in the rat’s small intestine. At different concentrations of puerarin (50，100，200μg/mL), the intestinal absorption rate constants (Ka) were 0.021/h, 0.030/h, 0.020 /h-, and absorption percentage were19.28%、21.78%、16.98%, respectively. The intestinal absorption experiments of rats (in situ) showed the absorption of puerarin was a first-order process and the mechanism of absorption was passive diffusion transport.