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Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease |
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| Authors: | Lu Xiangfeng Wang Laiyuan Chen Shufeng He Lin Yang Xueli Shi Yongyong Cheng Jing Zhang Liang Gu C Charles Huang Jianfeng Wu Tangchun Ma Yitong Li Jianxin Cao Jie Chen Jichun Ge Dongliang Fan Zhongjie Li Ying Zhao Liancheng Li Hongfan Zhou Xiaoyang Chen Lanying Liu Donghua Chen Jingping Duan Xiufang Hao Yongchen Wang Ligui Lu Fanghong Liu Zhendong Yao Cailiang Shen Chong Pu Xiaodong Yu Lin Fang Xianghua Xu Lihua Mu Jianjun Wu Xianping Zheng Runping Wu Naqiong Zhao Qi Li Yun Liu Xiaoli Wang Mengqin Yu Dahai Hu Dongsheng Ji Xu Guo Dongshuang Sun Dongling Wang Qianqian Yang Ying Liu Fangchao |
| Institution: | State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. |
| Abstract: | We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population. |
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